Vettel needs to find a way to hit back at Singapore Grand Prix Lights inside SMX hall flicker as Duterte rants vs Ayala, Pangilinan anew Tim Cone, Ginebra set their sights on elusive All-Filipino crown MOST READ Lights inside SMX hall flicker as Duterte rants vs Ayala, Pangilinan anew Gretchen Barretto’s daughter Dominique graduates magna cum laude from California college Carpio hits red carpet treatment for China Coast Guard PLAY LIST 02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player award LATEST STORIES View comments Japeth Aguilar embraces role, gets rewarded with Finals MVP plum Sanchez bounced a 2-2 pitch to Jackie Bradley Jr. in the dirt and past catcher Danny Jansen to the backstop, allowing Devers to score.“I love Price. I keep in touch with Price even to this day,” said Sanchez, who was teammates with Price in Toronto in 2015. “To go out there and match what he’s doing. … Just to go out there and have a special night like that was fun. It’s unfortunate they scored the way they did and we lost the way we did.”Toronto fell to 1-8 at Fenway Park this year and dropped to a season-worst 15 games below .500.DOUBLE DUTYRowdy Tellez has seven doubles in his first seven games, the most for any player in the majors since 1908. Jonathan Davis had his first major league hit for Toronto, which hasn’t won back-to-back games since Aug. 24-25.CENTURY CLUBCora is the first manager with 100 wins in his first season with a club since Felipe Alou with the 2003 San Francisco Giants and the first in his initial season as a big league manager since Dusty Baker with the 1993 Giants.FOR SALECora said Chris Sale, who returned to the mound on Tuesday night for the first time since Aug. 12, did not report any issues with his left shoulder. Sale was scheduled to play catch on Wednesday and throw a bullpen session on Friday. The plan is for him to pitch three innings against the New York Mets.“He’s encouraged,” Cora said. “Yesterday was like his first big league outing. He was all over the plate. He admitted it — the game sped up on him.” A night after becoming the first major league team this year to clinch a playoff spot, Boston won for the 10th time in 14 games and moved a season-high 54 games above .500 for the first time since the 1946 team of Williams, Johnny Pesky, Bobby Doerr and Dom DiMaggio went 104-50.The Red Sox need only to go 6-10 the rest of the season to break the franchise record of 105 wins, set in 1912. Boston also won 101 games in 1915.“Somebody just told me it’s been done three times here and the last one was 70-something years ago,” first baseman Mitch Moreland said. “I think that speaks for itself.”BLUE BLUE JAYSSanchez allowed three hits and struck out six, allowing the game’s only run after Moreland walked to lead off the fifth. Devers reached on a fielder’s choice and took third when Brock Holt poked a single through the hole at shortstop on a hit-and-run.ADVERTISEMENT TRAINER’S ROOMBlue Jays: RHP Marcus Stroman, who hasn’t pitched since Sept. 3 because of a blister on his right index finger, may be done for the year, manager John Gibbons said.Red Sox: RHP Matt Barnes who hasn’t pitched since Sept. 4 because of left hip inflammation, played catch on Monday and Tuesday, and he was scheduled to do so again on Wednesday.UP NEXTBlue Jays: RHP Sam Gaviglio (3-8) pitches the series finale on Thursday night.Red Sox: LHP Eduardo Rodriguez (12-4) takes the mound for Boston.Sports Related Videospowered by AdSparcRead Next Allen Durham still determined to help Meralco win 1st PBA title “That’s what we’ve done all year,” Price said on Wednesday night after pitching seven innings of three-hit ball to beat the Toronto Blue Jays 1-0. “That’s why we have 100 wins right now.”Price (15-6) struck out seven to win his sixth straight decision, leaving after 92 pitches with a lead earned when Rafael Devers scampered home on a wild pitch by Aaron Sanchez (4-6) in the fifth inning. The Red Sox left-hander is unbeaten in 11 starts and is 5-0 with a 1.56 ERA in five starts since the All-Star break.FEATURED STORIESSPORTSGinebra beats Meralco again to capture PBA Governors’ Cup titleSPORTSJapeth Aguilar wins 1st PBA Finals MVP award for GinebraSPORTSGolden State Warriors sign Lee to multiyear contract, bring back ChrissSteven Wright pitched the eighth and Craig Kimbrel got three outs for his 39th save, and Boston’s magic number for clinching the AL East dropped to seven over the second-place New York Yankees.“Don’t get me wrong; 100 is 100. But we’ve got bigger goals, obviously,” Red Sox manager Alex Cora said. “Today we got closer to one of those goals.” “100 Wins” is posted on the outfield display after the Boston Red Sox defeated the Toronto Blue Jays 1-0 for their 100th win of the season after a baseball game at Fenway Park in Boston, Wednesday, Sept. 12, 2018. (AP Photo/Charles Krupa)BOSTON — The scoreboards at Fenway Park were all flashing “100 WINS” to celebrate the Red Sox reaching the milestone for the first time since Ted Williams returned from World War II.David Price was already thinking about No. 101.ADVERTISEMENT Gov’t to employ 6,000 displaced by Taal Nadine Lustre’s phone stolen in Brazil Don’t miss out on the latest news and information. Phivolcs: Slim probability of Taal Volcano caldera eruption
Students from Loreto Convent are fundraising in Letterkenny Shopping Centre this afternoon for youth mental health organisation Jigsaw.They have a Microsoft Surface Pro 4 to give away and The Little Things book to sell. The laptop and accessories are worth over €1200! Tickets will be €2 for a line or €5 for 3 lines and can be bought at Letterkenny Shopping Centre.For more see their Facebook page.Students host raffle with prize worth over €1,200 in aid of Jigsaw was last modified: October 22nd, 2016 by Elaine McCalligShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)
Imagine how cool it would be to get in your car and have the road do the driving. The highway would stretch or shrink, moving this way or that, till you saw your destination and hopped off. That appears to be what the cargo-bearing motors do in the cells in your body. A new paper by a team of American biophysicists published the hypothesis in PNAS this week.1 Cell biologists have known for a long time that molecular motors move cargo around on long strands of protein, called microtubules, that form an intracellular highway network (12/04/2003) called the cytoskeleton. One observation that has been confusing, though, is why the motors seem to just move back and forth (bidirectional transport) instead of making progress toward a destination. It doesn’t seem to make any sense. Would a car that has to get somewhere just keep shifting between forward and reverse gears? It starts to make better sense when you consider that the road is also doing the moving. The situation in a cell is much more complex than suggested above. The cell is a crowded environment, with enzymes and parts moving about rapidly. In addition, there is thermal motion adding to the hustle and bustle. Microtubules grow and shrink as their molecular components are added and removed constantly. Cargo-carrying motors, like dynein and kinesin, attach and detach from their freeways all the time. It seems chaotic, but the cell works. Somehow it is a powerhouse of organization and function. The authors of this new idea proposed that any given cargo vesicle has multiple motors attached to multiple tracks at a time. These motors can work in concert, tugging on the microtubules, making them bend and buckle at times. Think of what could happen if cars could do this on a 3-D freeway system, in which they had attachments to multiple tracks at once. They could compress the road, let go of the overhead track, and then shoot out quickly for miles as the road beneath them stretched back to its extended position. Some vehicles along for the ride could get a free ride – like on a moving sidewalk that advances by un-stretching itself. Is this a novel concept, or what? Here’s how the authors explained it, after first dismissing other possibilities:Given these observations, a more parsimonious explanation is that nonthermal (motor-induced) forces and quenched disorder constraining the microtubule backbones within the cell body generate large backbone undulations. Numerous constraints are imposed by the crowded intracellular environment, forcing the microtubule backbone into an effective highly curved confining tube, in particular through entanglement with other microtubules. The large stored length of microtubules (within the cell body) is transmitted over long distances by the virtually incompressible microtubules and projected in the longitudinal direction inside the processes…. … The fluctuating tensions are induced by multiple molecular motors decorating intracellular cargos and cross-bridging between several microtubules at a time. The microtubule network actively “animated” in this fashion induces an additional velocity component that adds to the motor-driven cargo transport velocities in the microtubule fixed reference frame.A cell’s molecular motors thus drive the road as well as the car! With this mechanism, they get a velocity boost that helps them arrive at their destinations faster than if they simply moved along the microtubule at constant velocity. This also begins to explain why the motors move back and forth:As suggested by our data, within the “fluctuating cytoskeleton” picture we can indeed understand the observed back-and-forth motion as a consequence of a peculiar form of tug of war of many motors competing with each other and with microtubule elastic forces. As opposed to the “local” tug of war of opposite polarity motors on the same vesicle, the “global” tug of war described here allows large numbers of motors distributed along the whole microtubule to exert forces at a time and compete for the direction of microtubule movement. When bent on large scales, the microtubules offer a rather large compliance to the exerted longitudinal and lateral forces, which in turn allows all of the motors along their length to act at a time and generate the observed microtubule fluctuations. Switching of motor pulling and microtubule relaxation phases can induce a back-and-forth motion of the microtubule backbone.But a question remains. How does this help the motor get its attached cargo get to its destination? Simple: it hitchhikes. This is actually the term they suggested to describe their hypothesis. Some motors only need a short hop. They grab the moving microtubule and let go when they need to. Others, needing rapid transit across longer distances, play the system by binding and unbinding repeatedly. In a matter of seconds, the motor can cover a long distance (relative to its own tiny size). The moving-sidewalk system even works for cargos without their own motors. “For this mode of motility involving transient binding of cargos to moving microtubules, which eventually leads to a long-range dispersion, we suggest the term ‘hitchhiking,’” they said. “Exploiting this simple mechanism, even cargos devoid of active motors can be efficiently dispersed throughout the entire cell.” In short,“We demonstrate that, besides being tracks for motors that directly haul cargos, microtubules can transmit the force of distant motors onto a cargo over large separations.”2 1. Kulik, Brown, Kim, Kural, Blehm, Selvin, Nelson and Gelfand, “The role of microtubule movement in bidirectional organelle transport,” Proceedings of the National Academy of Sciences USA, Published online before print July 14, 2008, doi: 10.1073/pnas.0800031105.2. Physicists may enjoy this extra detail: This implies a mechanical nonlocality of the cytoskeleton because a longitudinal pulling strain in an almost stretched microtubule is essentially instantaneously transmitted over long distances. Furthermore, microtubule motion on intermediate timescales (tens of milliseconds to several seconds) can be understood as a consequence of pulling out the slack length of microtubules induced by random constraints and motor forces along its entire length.”Frequent readers of CEH will know immediately the answer to this pop quiz question. “True or false: evolution was mentioned in this paper.” (Answer: false). As amazing as this explanation was, other questions come to mind. How does the motor know where to get on and off? How do the motors conspire to control the microtubules for best effect? Remember, these are blind molecules in a busy, seemingly chaotic environment. The results, however, are anything but chaotic. There are wonders in this black box we are only beginning to appreciate.(Visited 11 times, 1 visits today)FacebookTwitterPinterestSave分享0
16 July 2012 South Africa saw exceptional growth in tourist arrivals in the first quarter of 2012, says Tourism Minister Marthinus van Schalkwyk. Launching the latest tourist arrival figures in Pretoria on Sunday, Van Schalkwyk said that overall tourist arrivals to the country grew by 10.5% in the first quarter of 2012, with strong growth coming from all regions. The period from January to March 2012 saw a total of 2 267 807 tourist arrivals to South Africa – 216 031 more than the same period in 2011. ‘Strong positive growth trends’ He also announced that overseas tourist arrivals were up by a combined 17.8%, and arrivals from Europe grew by 11.9%. South Africa’s biggest overseas source market, the United Kingdom, recovered from an overall decline in 2011 to post positive returns of 9.5% – with 133 729 tourists visiting South Africa in the first three months of 2012. Tourist arrivals from Germany maintained a strong positive growth trend, and with a 15.2% growth rate, the country was among the best-performing markets on the European continent. These were wonderful results for “the destination, the country, the tourism industry and the economy”, Van Schalkwyk said. “Robust sales and marketing partnerships across the region, South Africa’s accessibility, and the exceptional value for money that the destination offers to European travellers were significant contributing factors to tourist arrivals growth from Europe,” he said. The United States also returned excellent growth of 16.1% as South Africa maintained its status as a desirable and coveted leisure holiday experience for American travellers.Higher growth from emerging markets South Africa also continued to enjoy growth from the emerging markets during the first quarter of this year. Brazil posted 71.7% growth, India grew by 23.1% and tourist arrivals from China increased by 67.7%. In total, the regional Asian market returned tourist arrivals growth of more than 43%, delivering 85 189 tourists against 59 549 tourists for the same three months last year. Tourist arrivals from regional African tourist markets also achieved positive growth rates of 7.9%, with Angola up 48.5%, Nigeria showing 26.7% growth and Tanzania with 31.4% growth. The three stood out as exceptional continental-market achievers in the first three months of the year. Van Schalkwyk said this overall growth could be ascribed to significant investments in the South African tourism industry in time, energy and resources. These included a series of trade workshops across key markets, numerous travel, trade and media familiarisation trips hosted by South Africa, as well as ongoing in- depth research into consumer needs. South Africa’s valuable partnerships and determination to defend and grow its traditional tourist markets were now yielding dividends, as the industry had worked hard during difficult times, Van Schalkwyk said. “We are extremely lucky to live in South Africa and to enjoy in our own backyard a destination that has grown tremendously in popularity and desirability all over the world. “Let’s work together and encourage each other to continue to make tourists feel at home, to travel South Africa ourselves like tourists in our own country and to continue offering the excellent service, value for money and accessibility that have delivered these exceptional results, which we are optimistic will continue well into the future,” he said. Source: SANews.gov.za
Top Reasons to Go With Managed WordPress Hosting A Web Developer’s New Best Friend is the AI Wai… mike melanson Why Tech Companies Need Simpler Terms of Servic… Tags:#advertising#Google#news#web Related Posts Google knows you. It knows what type of car you drive from that time, last year, when you looked up the where you could find a cheap set of tires. It knows that you like Mexican food from all the times you’ve looked on Google Maps. And Google knows how to leverage this type of information with services like Google AdWords, AdSense, and DoubleClick Ad Exchange but now it’s moving into what it’s calling “the next generation of ad serving” – a simplified, streamlined ad server.While Google currently has the upper hand in the battle, it’s starting to look more and more like Google and Facebook are about to duke it out in the advertising arena. And who will they be battling over? The little guy.Google’s latest move in the advertising sphere replaces DoubleClick DART and Google Ad Manager with DoubleClick for Publishers, an ad management system meant to simplify the more complex aspects of managing ad space.According to an article on PaidContent, this latest move by Google “involves the promise of greater simplicity as it aims for smaller publishers”. DoubleClick for Publishers offers a simple, free version of DFP for small businesses and another (not free) for larger websites – likely customers of DoubleClick DART.The new service offers a redesigned interface, more detailed reporting, algorithms to automatically improve ad performance and a public API to allow for third-party apps to use the DFP system. DFP will allow its users to perform a number of functions, from running different ads at different times, according to when they best perform, to mixing and matching different priced ads to various page locations. We think that the increased focus on small businesses is a growing trend in online advertising, as we just saw with Facebook announcing last week that it would begin accepting PayPal for advertising. It seems that many of these big companies are realizing that they may be missing out on innumerable revenue streams from small businesses by making the task of advertising daunting and complicated. A dollar is a dollar, after all, and increasing accessibility while reducing confusion should only increase the number of dollars coming in. 8 Best WordPress Hosting Solutions on the Market
Role of Mobile App Analytics In-App Engagement Apple, mobile developers and designers had 98 days of summer to play with the iOS 7 beta. Now it is time for everyone else with the public release of iOS 7.Apple latest version of its mobile operating system for iPhones, iPod Touch and iPads is officially available to the public as of 1 p.m. EDT today. In addition to the new iPhone 5S and iPhone 5C, Apple is making iOS 7 available to most of its other iOS-based mobile devices. Older versions of the iPhone will be able to receive the update all the way back to the iPhone 4 (which includes the iPhone 4S and iPhone 5). The iPad 2, as well as the third and fourth generation of iPads and iPad Mini, will receive the update, as will the fifth-generation iPod Touch (but no earlier iPod Touch generations will get iOS 7). To install iOS 7 on your device, you can go to the “Settings” icon and go to the “General” menu item. Tap the “Software Update” button (underneath the “About” button) and download the update. Once the download is complete, you can install the update.You can also upgrade to iOS 7 through the newest version of iTunes 11.1. Plug your iPhone, iPod or iPad into your computer and find it on the menu button within iTunes. See also: How To Downgrade The iOS 7 Beta Back To iOS 6 The Easy WayAs with any time you update software, be sure to backup all your files (pictures, contacts, texts, etc.) before downloading and installing a new version of an operating system. Remember to have your device plugged in or charged to at least 50% of battery capacity before downloading the update.Note that if your iOS 7 compatible device is having trouble downloading the upgrade right now, it is likely because Apple’s servers are extremely busy handling the influx of requests. This is nothing to be alarmed about and happens every year when Apple releases the new public version of iOS. Try again in a few hours after the rush and it should download just fine. dan rowinski Related Posts Tags:#Apple#iOS 7 What it Takes to Build a Highly Secure FinTech … Why IoT Apps are Eating Device Interfaces The Rise and Rise of Mobile Payment Technology
Several leading newspapers in the Kashmir Valley ran their editorial spaces blank on Tuesday in protest against the killing of journalist and editor of daily Rising Kashmir Shujaat Bukhari.A spokesman of the Kashmir Editors Guild (KEG) said the decision to leave the space blank was taken in a meeting on Monday afternoon “to lodge a strong protest against the killing of the scribe”.The editorial space of all major English dailies like Greater Kashmir, Kashmir Times, Kashmir Observer and Kashmir Monitor were left blank.Bukhari, 50, was assassinated by at least three gunmen on June 14 outside his office. His two security guards were also killed in the attack. The Kashmir Press Club’s coordination committee also held a condolence meeting in Srinagar. “The members said that the entire journalistic fraternity of Kashmir is yet to come out of the shock of Shujaat’s killing and does not know how the void created by the brutal murder will be filled,” said the spokesman.Meanwhile, Director General of Police S.P. Vaid said the police has laid hands on “crucial leads in the case”.The Separatist Joint Resistance Leadership called for a complete strike on Thursday against the killing of Bukhari.
New Delhi, Jul 27 (PTI) Tata Motors owned Jaguar Land Rover (JLR) today said it has launched Range Rover SVAutoiography Dynamic in India, priced at Rs 2.79 crore (ex- showroom).The SUV comes loaded with several features and a powerful V8 engine.”The Range Rover SVAutobiography Dynamic is designed and engineered by JLR?s special vehicle operations (SVO) team who are passionate in their commitment to explore new frontiers of luxury, performance and technology,” JLR India Managing Director Rohit Suri said in a statement.Range Rover SVAutobiography Dynamic is the fourth vehicle to join the brands portfolio in India after the Range Rover SVAutobiography, Range Rover Sport SVR and Jaguar F-TYPE SVR.The new model is available to order at all 25 authorised retail outlets in India, the company said. PTI MSS BAL
West Ham boss Pellegrini still keen on Medelby Paul Vegas10 months agoSend to a friendShare the loveWest Ham boss Manuel Pellegrini remains keen on Gary Medel.The Mirror says former Cardiff midfielder Medel could be heading back to England.Reports in Turkey say West Ham have held talks with Besiktas over the Chilean.The Hammers are reportedly ready to make an £8m bid.And Besiktas are prepared to sell as they seek to balance the books this month. TagsTransfersAbout the authorPaul VegasShare the loveHave your say
O.J. Howard VideoVideos of athletes going unrecognized when taking to the street and interviewing unsuspecting fans are always a good watch. This clip featuring Alabama tight end O.J. Howard is no different. Howard speaks with a slew of seemingly clueless Crimson Tide fans who have no idea who they’ve been approached by. Howard even asks one of them which tight end on the roster he thinks will stand out most next year and the fan cites TY Flournoy-Smith, Howard’s back-up. Howard hauled in 17 passes for 260 yards and no touchdowns in 2014. A gifted athlete, he should be a bigger factor in Alabama’s offensive attack this fall as a junior. If that happens, it’s unlikely he’ll be able to sneak up on any more fans.